The play is about Eugene and his older brother, Stanley, working together toward being comedy writers for the radio, and, eventually, television. They discover that their father, Jack, has been cheating on their mother, Kate. It is obvious to the family before Jack even admits it, and they try to find ways for Kate to cope with the loss when Jack may eventually leave. Jack reveals that the woman he has been seeing is dying.
When Eugene and Stanley find a job where they can write short comedic skits for the radio, they obscurely make fun of their own family. Jack can hear the similarities between the fictional family in the broadcast and their own family, and becomes outraged. He gets into a major argument with Stanley, which turns into an argument about Jack's affair.
In the end, the brothers receive some great job offers, and everyone moves on as life progresses in it's unstoppable march forward.
This is the third in the trilogy, following Brighton Beach Memoirs and Biloxi Blues.